To harness the regenerative potential of orthobiologics, a form of regenerative medicine, it is imperative to evaluate and understand various factors associated with healing and tissue regeneration. the types and concentrations of cells, growth factors, cytokines, and chemokines contained within orthobiologic products. Furthermore, the effects of these constituents on the local and systemic environment (both chemical and cellular) are investigated using in vitro and in vivo models. Viral vectors are used to perform gene manipulation research to alter the course of degenerative diseases of the musculoskeletal system such as osteoarthritis. This foundational research enables to develop new regenerative medicine techniques and refine established ones.
Based on the basic science studies performed in our labs, novel orthobiologic treatments using growth factors, stem cells and gene therapy can be rapidly translated into clinical practice where further research can be performed to determine safety, efficacy and cost-effectiveness.